Receptor Antagonists Modulator Of Abuse Potential Of Drugs

5-HT3 RECEPTOR ANTAGONISTS: MODULATOR OF ABUSE POTENTIAL OF DRUGS Abstract Serotonergic system in brain creates an important network for proper functioning of brain. It plays an integral role in regulating A9 as well as A10 dopaminergic neurons in basal neuronal circuit. The 5-HT3 receptors are found to be the only ionic receptors in serotonergic family of receptors regulating several important functions of brain. The abuse drugs lead to dopamine increase in nucleus accumbens. This paper reflects on role of 5-HT3 antagonists in modulating the abuse potential of drugs. Among all the abuse drugs, 5-HT3 receptors are found to be most effective in condition of alcoholism. Moreover, there are evidences of neuroadaptive changes in brain after chronic use of 5-HT3 antagonists. All these studies led to identify site of action of alcohol and other abuse drugs on 5-HT3 receptor which is found to be different than the orthosteric site. CONTENTS 1. History of 5-HT3 2. Discovery of 5-HT receptors 3. Structure of 5-HT3 receptor 4. Mechanism of action of 5-HT3 receptor 5. Distribution of 5-HT3 receptor 5.1. Mesocorticolimbic pathway 5.2. Prefrontal cortex 6. Alcohol and 5-HT3 receptor 6.1. Electrophysiological Analysis: Potentiation of 5-HT3 activity by Alcohol 6.2. Inhibitory activity of Alcohol 6.3. Alcohol binding site on 5-HT3 receptor 7. Role of 5-HT3 antagonists 7.1. 5-HT3 antagonists and Dopamine 7.2. 5-HT3 antagonists: Abuse potential 7.2.1. 5-HT3 antagonists and Alcohol 7.2.2.Show MoreRelatedFuture Medications and Newer Drugs3158 Words   |  13 PagesIntroduction This chapter deals with the newer drugs available in all classes of psychiatric disorders. Anxiety (Social Phobia) Anxiety disorders affect more than 40 million adults in the U.S., with about 15 million of those suffering from acute social phobia, according to the National Institute of Mental Health. The drug, which has a unique mechanism of action, is administered in an intranasal spray and acts with rapid-onset on peripheral receptors from nasal chemosensory neurons that act on theRead MoreMedications Essay1741 Words   |  7 Pagescategories will be automatically identified by the software based on the lists that follow. The user will be provided with the appropriate section on Jon’s list that provides both a list of related medications within this category and comments on the potential impact on testing.) Pain Medications: Opiates and synthetic opioids (Morphine, Dilaudid, Tylenol #3, Vicodin, Oxycontin, Tramadol, Fentanyl, Oxycodone, Codeine, Methadone) Comment: These medications tend to be habit forming, tend to induceRead MoreSubstance Abuse And Alcohol Abuse3037 Words   |  13 PagesSubstance abuse is use of a substance (drug) or alcohol in which the person consumes the substance/alcohol in amounts or with different methods which are harmful for themselves or others. Substance abuse and addictions are run in families. Alcohol drinking can be defined in many types as following- Social drinking is defined as occasional drinking in a social setting without an intention to get drunk. Binge drinking is defined as consumption of alcohol in excess of which is socially acceptable,Read MoreEssay On Phencyclidine4300 Words   |  18 Pagesantipsychotics [7]. Moreover, a number of recent studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) as adjuncts to antipsychotic drugs are effective for treating schizophrenia [8,  9]. Therefore, the pathological process underlying schizophrenia may involve neuroinflammatory responses in the central nervous system (CNS). Noncompetitive  N-methyl-d-aspartate (NMDA) receptor antagonists, including phencyclidine (PCP), evoke schizophrenia-like psychosis and cognitive deficits in healthyRead MoreGsk Annual Report 2010135604 Words   |  543 Pageslong-standing legal matters. This belies the good progress we have made to execute our strategy and which is evident in diversiï ¬ ed underlying sales growth and the increasing potential of our pipeline. We believe GSK is becoming a more balanced, synergistic business with a lower risk proï ¬ le and the option for signiï ¬ cant potential upside from the pipeline. GSK is also a business built on strong values and a deep commitment to operating with integrity. In 2010 we have taken further steps to make our company